B1 Benfotiamine (190mg) with B3 Niacinamide (40mg).Living Labs

Living Labs Benfotiamine + Niacinamide

Advanced B-Vitamin Support for Diabetic Health

Living Labs brings you a premium blend of Benfotiamine (active B1) and

Niacinamide (B3 derivative) - a synergistic formula designed to protect against the hidden damage of

high blood sugar, nerve damage, and oxidative stress to your eyes, your kidneys, and your blood vessels.

Without Benfotiamine, glucose metabolism stalls; without niacinamide, the energy harvested from glucose cannot be fully

utilized. The combined use of Benfotiamine and Niacinamide strengthens mitochondrial energy, nerve protection, and

antioxidant defence.

Benfotiamine (Vitamin B1 derivative)

Benfotiamine is a fat-soluble form of thiamine (Vitamin B1). It's superior and up to 15 times more bioavailable than

standard thiamine and is especially noted for:

• Supporting glucose metabolism
• Reducing the formation of advanced glycation end-products (AGEs)
• Protecting nerves, blood vessels, and mitochondria from oxidative stress

Vitamin B3 (Niacin, Niacinamide, NAD+ precursors)

Vitamin B3 is essential for generating NAD+/NADH and NADP+/NADPH - cofactors central to cellular energy production,

antioxidant defense, and repair mechanisms.

Together, Benfotiamine and Niacinamide

Benfotiamine (fat-soluble B1) supports proper carbohydrate breakdown and helps reduce toxic byproducts, while Vitamin B3

(niacin/niacinamide) supports the electron carriers (NAD+/NADH and NADPH) needed to process that fuel and sustain

cellular repair.

Summary

• Blood sugar support
• Supports nerve and vessel health by reducing harmful byproducts of glucose metabolism
• Protects eyes, kidneys, and circulation from AGE-related stress
• Boosts cellular energy and repair through NAD+ support

This unique combination helps you safeguard long-term health and maintain vitality - without compromising quality.

Factors That Deplete Thiamine (Vitamin B1)

Based on published research (Cells Journal, MDPI, 2021)

Thiamine deficiency is far more common than most realize. Research has reported measurable deficiency rates ranging from

approximately 20% to 90% across multiple populations - even when blood levels appear "normal." This suggests that modern

lifestyle demands may exceed the current RDA for many people.

Even mild insufficiency can impair nerve, brain, and metabolic function - linking low thiamine status to fatigue,

neuropathy, low mood, cognitive decline, and poor glucose metabolism.

Why Thiamine Depletes So Easily

Thiamine has a short half-life, minimal body storage, and can be disrupted by chemicals, medications, and modern food

processing.

Key depletion factors include:

1. High-Carbohydrate Diets

High sugar and refined starch intake increases thiamine demand because thiamine is essential for glucose metabolism.

Chronic overconsumption without adequate replenishment can drive depletion.

2. Processed Food Chemicals

Preservatives, colorants, and flavoring agents used in modern foods may degrade thiamine or interfere with absorption,

worsening deficiency risk in processed-diet populations.

3. Alcohol, Tobacco, Coffee, and Tea

These can reduce thiamine uptake and accelerate urinary excretion. Chronic use can deplete reserves even in otherwise

healthy individuals.

4. Medications and Environmental Toxins

Thiamine (Vitamin B1) deficiency is associated with a wide range of metabolic, neurological, cardiovascular, and

cognitive problems. What is often overlooked is that some of the very medications used to manage these conditions can

further worsen an underlying thiamine deficit.

This creates a medical paradox:

The disease linked to thiamine deficiency is often worsened by the drugs prescribed to treat it.

Many widely used medications may reduce thiamine levels, block absorption, or interfere with enzymes that rely on

thiamine. This can deepen deficiency and intensify symptoms - especially in people already vulnerable due to diabetes,

metabolic stress, neurological illness, or chronic inflammation.

Key drug classes that may worsen thiamine deficiency

• 1. Glumetza (for diabetes)

• Glumetzasupports glucose control, but research suggests it may lower thiamine status through mechanisms such as:

• Reducing intestinal absorption
• Increasing renal loss
• Interfering with thiamine-dependent enzymes

This matters because diabetes itself is associated with very high rates of low thiamine status, and further depletion

may intensify:

• Neuropathy
• Fatigue
• Impaired glucose metabolism
• Cardiovascular risk

2. Psychiatric medications (SSRIs, mood stabilizers)

These medicines may increase metabolic demand and may impair nutrient handling in susceptible individuals. Lower

thiamine status can worsen:

• Low mood and anxiety
• Cognitive performance
• Fatigue
• Mitochondrial energy output

Thiamine insufficiency has been reported in a meaningful portion of individuals with psychiatric disorders.

3. Certain antibiotics >

Some antibiotics may interfere with thiamine activation or act as functional antagonists in the body. This can

aggravate:

• Brain fog
• Nerve irritation
• Muscle weakness
• Slower recovery during illness

Frequent or repeated antibiotic exposure may increase long-term nutrient vulnerability in some individuals.

4. Anti-hypertensives, NSAIDs, aspirin, and acetaminophen

These medicines are used daily by millions. Some may:

• Increase urinary excretion of thiamine
• Interfere with thiamine-dependent enzymes
• Reduce mitochondrial energy output in vulnerable individuals

This may contribute to worsening:

• Fatigue
• Poor circulation
• Nerve dysfunction
• Chronic pain patterns

The Resulting Cycle

• Thiamine depletion contributes to disease and dysfunction.
• Medications prescribed for those conditions may further deplete thiamine.
• Symptoms worsen, leading to more medication, deeper depletion, and greater dysfunction.

Why This Matters

Understanding this pattern is essential for long-term health. Many people experience persistent symptoms that do not

fully resolve - not necessarily because medication "fails," but because the underlying depletion pattern is never

addressed.

Supporting thiamine pathways - especially with forms that effectively enter cells, such as Benfotiamine,

often paired with Niacinamide (B3) - may help break this cycle by supporting cellular energy and

metabolic stability.

Conclusion

Modern living creates a perfect storm for thiamine depletion: high-carbohydrate diets, processed foods, chronic stress,

and long-term medication use can all contribute. Even when lab tests show "normal" results, functional deficiency may

persist at the cellular level, impairing metabolism and nervous system health.

This is why active thiamine forms like Benfotiamine, combined with Niacinamide (B3),

can provide a more effective strategy to support energy production and help protect the body from modern metabolic

stress.

What's in the box
1 x Bottle B1 Benfotiamine with B3 Niacinamide